GMC redesigned its full-size vans for the first time in seven years for the 2003 model year. The 2003 Savanas got upgraded powertrains, fresh features and an updated appearance. Three industry firsts in full-size vans were available: all-wheel drive, an optional left-side door and unique side access panels for use on commercial vans. Front-end styling was revised to give the Savana a greater family resemblance to other General Motors' trucks.

GM's StabiliTrak electronic stability system was added to 15-passenger models in 2004. Chevrolet's Express is closely related to the Savana and sells far better. For 2005, StabiliTrak is also standard on regular-wheelbase 12-passenger vans.