The National Highway Traffic Safety Administration gave the 2007 Yukon a five-star frontal crash-test rating; it hasn't done a side-impact test as of this writing. Rollover ratings were listed at three stars, which means in a single-vehicle crash the Yukon has a 22 - 24 percent chance of rolling over. That's about average for SUVs of this class. The Insurance Institute for Highway Safety has not yet rated the Yukon or any other new full-size SUV.

The Yukon Denali is equipped with plenty of safety features, including side curtain airbags for all three rows of seats. It has four-wheel antilock brakes, stability control and a rollover mitigation system. All wheel drive is also standard.